SrasV1, Main, Exploration, bibRecord, 005B32

Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Commentary

Identifieur interne : 005B32 ( Main/Exploration ); précédent : 005B31; suivant : 005B33

Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Commentary

Auteurs : Jan Ter Meulen [Pays-Bas] ; Alexander B. H. Bakker [Pays-Bas] ; Edward N. Van Den Brink [Pays-Bas] ; Gerrit J. Weverling [Pays-Bas] ; Byron E. E. Martina [Pays-Bas] ; Bart L. Haagmans [Pays-Bas] ; Thijs Kuiken [Pays-Bas] ; John De Kruif [Pays-Bas] ; Wolfgang Preiser [Allemagne] ; Willy Spaan [Pays-Bas] ; Hans R. Gelderblom [Allemagne] ; Jaap Goudsmit [Pays-Bas] ; Albert D. M. E. Osterhaus [Pays-Bas] ; A. R. Foxwell [Australie] ; A. W. Cripps [Australie]

Source :

Lancet : (British edition) [ 0140-6736 ] ; 2004.

RBID : Pascal:04-0452196

Descripteurs français

KwdFr :
- Animaux, Anticorps monoclonaux (usage thérapeutique), Femelle, Furets, Humains, Immunisation passive, Immunoglobuline G (immunologie), Poumon (anatomopathologie), Poumon (virologie), Réplication virale, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (immunologie), Virus du SRAS (isolement et purification).
MESH :
- anatomopathologie : Poumon, Syndrome respiratoire aigu sévère.
- immunologie : Immunoglobuline G, Virus du SRAS.
- isolement et purification : Virus du SRAS.
- usage thérapeutique : Anticorps monoclonaux.
- virologie : Poumon, Syndrome respiratoire aigu sévère.
Pascal (Inist)
- Animaux, Femelle, Furets, Homme, Anticorps monoclonal, Chimioprophylaxie, Coronavirus, Furet, Etude critique, Humains, Immunisation passive, Médecine, Animal, Réplication virale, Syndrome respiratoire aigu sévère, Vaccination, Recherche scientifique, Essai préclinique, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Homme, Médecine, Vaccination, Recherche scientifique.

English descriptors

KwdEn :
- Animal, Animals, Antibodies, Monoclonal (therapeutic use), Chemoprophylaxis, Coronavirus, Critical study, Female, Ferret, Ferrets, Human, Humans, Immunization, Passive, Immunoglobulin G (immunology), Lung (pathology), Lung (virology), Medicine, Monoclonal antibody, Preclinical trial, SARS Virus (immunology), SARS Virus (isolation & purification), Scientific research, Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (prevention & control), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Vaccination, Virus Replication.
MESH :
- chemical , immunology : Immunoglobulin G.
- chemical , therapeutic use : Antibodies, Monoclonal.
- immunology : SARS Virus.
- isolation & purification : SARS Virus.
- pathology : Lung, Severe Acute Respiratory Syndrome.
- prevention & control : Severe Acute Respiratory Syndrome.
- virology : Lung, Severe Acute Respiratory Syndrome.
- Animals, Female, Ferrets, Humans, Immunization, Passive, Virus Replication.

Abstract

SARS coronavirus continues to cause sporadic cases of severe acute respiratory syndrome (SARS) In China. No active or passive Immunoprophylaxis for disease Induced by SARS coronavirus Is available. We investigated prophylaxis of SARS coronavirus infection with a neutralising human monoclonal antibody In ferrets, which can be readily infected with the virus. Prophylactic administration of the monoclonal antibody at 10 mg/kg reduced replication of SARS coronavirus in the lungs of Infected ferrets by 3.3 logs (95% Cl 2.6-4.0 logs; p<0.001), completely prevented the development of SARS coronavirus-induced macroscopic lung pathology (p=0.013), and abolished shedding of virus In pharyngeal secretions. The data generated In this animal model show that administration of a human monoclonal antibody might offer a feasible and effective prophylaxis for the control of human SARS coronavirus infection.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112500

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Commentary</title>
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<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Spaan, Willy" sort="Spaan, Willy" uniqKey="Spaan W" first="Willy" last="Spaan">Willy Spaan</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Medical Microbiology, Leiden University Medical Centre</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gelderblom, Hans R" sort="Gelderblom, Hans R" uniqKey="Gelderblom H" first="Hans R." last="Gelderblom">Hans R. Gelderblom</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Robert Koch-institut</s1>
<s2>Berlin</s2>
<s3>DEU</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goudsmit, Jaap" sort="Goudsmit, Jaap" uniqKey="Goudsmit J" first="Jaap" last="Goudsmit">Jaap Goudsmit</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Crucell Holland BV</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Virology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Foxwell, A R" sort="Foxwell, A R" uniqKey="Foxwell A" first="A. R." last="Foxwell">A. R. Foxwell</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Gadi Research Centre for Medical and Health Sciences, University of Canberra</s1>
<s2>Canberra, ACT 2601</s2>
<s3>AUS</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Canberra, ACT 2601</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cripps, A W" sort="Cripps, A W" uniqKey="Cripps A" first="A. W." last="Cripps">A. W. Cripps</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>School of Medicine, Griffith University, Gold Coast Campus</s1>
<s2>Gold Coast, Queensland</s2>
<s3>AUS</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Gold Coast, Queensland</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Animals</term>
<term>Antibodies, Monoclonal (therapeutic use)</term>
<term>Chemoprophylaxis</term>
<term>Coronavirus</term>
<term>Critical study</term>
<term>Female</term>
<term>Ferret</term>
<term>Ferrets</term>
<term>Human</term>
<term>Humans</term>
<term>Immunization, Passive</term>
<term>Immunoglobulin G (immunology)</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Medicine</term>
<term>Monoclonal antibody</term>
<term>Preclinical trial</term>
<term>SARS Virus (immunology)</term>
<term>SARS Virus (isolation & purification)</term>
<term>Scientific research</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
<term>Severe Acute Respiratory Syndrome (prevention & control)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Severe acute respiratory syndrome</term>
<term>Vaccination</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps monoclonaux (usage thérapeutique)</term>
<term>Femelle</term>
<term>Furets</term>
<term>Humains</term>
<term>Immunisation passive</term>
<term>Immunoglobuline G (immunologie)</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (virologie)</term>
<term>Réplication virale</term>
<term>Syndrome respiratoire aigu sévère ()</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Virus du SRAS (immunologie)</term>
<term>Virus du SRAS (isolement et purification)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Immunoglobulin G</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Immunoglobuline G</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Ferrets</term>
<term>Humans</term>
<term>Immunization, Passive</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Furets</term>
<term>Homme</term>
<term>Anticorps monoclonal</term>
<term>Chimioprophylaxie</term>
<term>Coronavirus</term>
<term>Furet</term>
<term>Etude critique</term>
<term>Humains</term>
<term>Immunisation passive</term>
<term>Médecine</term>
<term>Animal</term>
<term>Réplication virale</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Vaccination</term>
<term>Recherche scientifique</term>
<term>Essai préclinique</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Médecine</term>
<term>Vaccination</term>
<term>Recherche scientifique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">SARS coronavirus continues to cause sporadic cases of severe acute respiratory syndrome (SARS) In China. No active or passive Immunoprophylaxis for disease Induced by SARS coronavirus Is available. We investigated prophylaxis of SARS coronavirus infection with a neutralising human monoclonal antibody In ferrets, which can be readily infected with the virus. Prophylactic administration of the monoclonal antibody at 10 mg/kg reduced replication of SARS coronavirus in the lungs of Infected ferrets by 3.3 logs (95% Cl 2.6-4.0 logs; p<0.001), completely prevented the development of SARS coronavirus-induced macroscopic lung pathology (p=0.013), and abolished shedding of virus In pharyngeal secretions. The data generated In this animal model show that administration of a human monoclonal antibody might offer a feasible and effective prophylaxis for the control of human SARS coronavirus infection.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Pays-Bas</li>
</country>
<region><li>Berlin</li>
<li>District de Darmstadt</li>
<li>Hesse (Land)</li>
<li>Hollande-Méridionale</li>
</region>
<settlement><li>Berlin</li>
<li>Francfort-sur-le-Main</li>
<li>Leyde</li>
<li>Rotterdam</li>
</settlement>
</list>
<tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Ter Meulen, Jan" sort="Ter Meulen, Jan" uniqKey="Ter Meulen J" first="Jan" last="Ter Meulen">Jan Ter Meulen</name>
</region>
<name sortKey="Bakker, Alexander B H" sort="Bakker, Alexander B H" uniqKey="Bakker A" first="Alexander B. H." last="Bakker">Alexander B. H. Bakker</name>
<name sortKey="De Kruif, John" sort="De Kruif, John" uniqKey="De Kruif J" first="John" last="De Kruif">John De Kruif</name>
<name sortKey="Goudsmit, Jaap" sort="Goudsmit, Jaap" uniqKey="Goudsmit J" first="Jaap" last="Goudsmit">Jaap Goudsmit</name>
<name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name>
<name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name>
<name sortKey="Martina, Byron E E" sort="Martina, Byron E E" uniqKey="Martina B" first="Byron E. E." last="Martina">Byron E. E. Martina</name>
<name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<name sortKey="Spaan, Willy" sort="Spaan, Willy" uniqKey="Spaan W" first="Willy" last="Spaan">Willy Spaan</name>
<name sortKey="Van Den Brink, Edward N" sort="Van Den Brink, Edward N" uniqKey="Van Den Brink E" first="Edward N." last="Van Den Brink">Edward N. Van Den Brink</name>
<name sortKey="Weverling, Gerrit J" sort="Weverling, Gerrit J" uniqKey="Weverling G" first="Gerrit J." last="Weverling">Gerrit J. Weverling</name>
</country>
<country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name>
</region>
<name sortKey="Gelderblom, Hans R" sort="Gelderblom, Hans R" uniqKey="Gelderblom H" first="Hans R." last="Gelderblom">Hans R. Gelderblom</name>
</country>
<country name="Australie"><noRegion><name sortKey="Foxwell, A R" sort="Foxwell, A R" uniqKey="Foxwell A" first="A. R." last="Foxwell">A. R. Foxwell</name>
</noRegion>
<name sortKey="Cripps, A W" sort="Cripps, A W" uniqKey="Cripps A" first="A. W." last="Cripps">A. W. Cripps</name>
</country>
</tree>
</affiliations>
</record>

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Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Commentary

Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Commentary

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